Recently, we present a study exploring the effects of andrographolide, a bioactive compound derived from the plant Andrographis paniculata (ฟ้าทะลายโจร). Andrographolide is known for its potential therapeutic benefits, but its side effects and the mechanisms behind them are not well understood. Our research utilized Saccharomyces cerevisiae to delve into these aspects.
Our findings revealed that andrographolide can be cytotoxic, especially under conditions where oxidative phosphorylation is active. The compound impacted several crucial cellular processes, including causing vacuole fragmentation, inducing endoplasmic reticulum stress, accumulating lipid droplets, elevating reactive oxygen species levels, and compromising cell integrity. Additionally, a novel observation from our study was that andrographolide prompted the precipitation of biomolecules secreted by the yeast cells, introducing an extra layer of stress.
This investigation enhances our understanding of the cellular impacts and potential toxicological pathways of andrographolide, providing valuable insights into both its therapeutic and adverse effects.
Our findings revealed that andrographolide can be cytotoxic, especially under conditions where oxidative phosphorylation is active. The compound impacted several crucial cellular processes, including causing vacuole fragmentation, inducing endoplasmic reticulum stress, accumulating lipid droplets, elevating reactive oxygen species levels, and compromising cell integrity. Additionally, a novel observation from our study was that andrographolide prompted the precipitation of biomolecules secreted by the yeast cells, introducing an extra layer of stress.
This investigation enhances our understanding of the cellular impacts and potential toxicological pathways of andrographolide, providing valuable insights into both its therapeutic and adverse effects.
