Journal article
Tanaporn Phetruen, Bloem van Dam, S. Chanarat
Antioxidants, 2023
Antioxidants, 2023
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DOI
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APA
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Phetruen, T., van Dam, B., & Chanarat, S. (2023). Andrographolide Induces ROS-Mediated Cytotoxicity, Lipid Peroxidation, and Compromised Cell Integrity in Saccharomyces cerevisiae. Antioxidants.
Chicago/Turabian
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Phetruen, Tanaporn, Bloem van Dam, and S. Chanarat. “Andrographolide Induces ROS-Mediated Cytotoxicity, Lipid Peroxidation, and Compromised Cell Integrity in Saccharomyces Cerevisiae.” Antioxidants (2023).
MLA
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Phetruen, Tanaporn, et al. “Andrographolide Induces ROS-Mediated Cytotoxicity, Lipid Peroxidation, and Compromised Cell Integrity in Saccharomyces Cerevisiae.” Antioxidants, 2023.
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@article{tanaporn2023a,
title = {Andrographolide Induces ROS-Mediated Cytotoxicity, Lipid Peroxidation, and Compromised Cell Integrity in Saccharomyces cerevisiae},
year = {2023},
journal = {Antioxidants},
author = {Phetruen, Tanaporn and van Dam, Bloem and Chanarat, S.}
}
Abstract
Andrographolide, a bioactive compound found in Andrographis paniculata, has gained significant attention for its potential therapeutic properties. Despite its promising benefits, the understanding of its side effects and underlying mechanisms remains limited. Here, we investigated the impact of andrographolide in Saccharomyces cerevisiae and observed that andrographolide induced cytotoxicity, particularly when oxidative phosphorylation was active. Furthermore, andrographolide affected various cellular processes, including vacuole fragmentation, endoplasmic reticulum stress, lipid droplet accumulation, reactive oxygen species levels, and compromised cell integrity. Moreover, we unexpectedly observed that andrographolide induced the precipitation of biomolecules secreted from yeast cells, adding an additional source of stress. Overall, this study provides insights into the cellular effects and potential mechanisms of andrographolide in yeast, shedding light on its side effects and underlying cytotoxicity pathways.
